Cane lupo, a black dog on a black night in Italy

Then Pasteur solved the problem of failed silk crops (diseased silk worms), cholera in chickens, anthrax in cattle and sheep, and, in the mid-1880s, rabies. He recognized that nerve tissue from a rabid dog injected into healthy dogs produced rabies. He then developed a weakened virus (although viruses were then unknown), now termed an attenuated virus, which prevented rabies in vaccinated animals. He found his vaccine was effective even after rabid bites had occurred.

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